Antidepressants and SSRI Amphetamines

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Antidepressants and SSRIs have been mentioned as possible treatments for people with depression. The potential link for treatment lies in a neurotransmitter generated in the brain called serotonin; indeed it is the second "s" in SSRI, (short for selective serotonin reuptake syndrome). SSRI is a class of drugs utilized in addressing depression and depression-related disorders. Some familiar products such as Prozak, Zoloft, Celexa or Paxil are in this class of drug. These are some of the best known SSRIs.

How SSRIs Work

Research indicates that depression is linked to the body's ability to properly process messages moving from one nerve cell in the brain to another. SSRIs essentially strive to enhance that process. People experiencing something like an emotional stupor in response to some relatively inconsequential event know what it's like to experience a momentary depression. When this temporary state becomes prolonged and begins affecting other parts of life, it can be depression or a depression-related disorder.

Selective serotonin reuptake inhibitors function by causing the neurotransmitters known as serotonin to remain in the synaptic gap between two nerve cells longer than usual. One cell releases a message to another cell and the registration of that message is conveyed back to the sending cell in a process known as reuptake. By preventing that transmission from being taken up by the original sending cell, the corresponding serotonin neurotransmitters essentially remain in the gap between the two cells longer than normal. The net effect is a greater capacity for messages to be moved along which ties in to mood.

Amphetamines as Medication

Amphetamines are a synthetic compound stimulant utilized to treat conditions such as attention-deficit hyperactivity disorder (ADHD), narcolepsy and chronic fatigue syndrome. It is also approved in certain weight-loss medications, for treating obesity and for depression (in special cases where other treatments have failed). Be certain to consult with your doctor before making any changes in your medications.

Amphetamines stimulate the central nervous system, and also act in ways similar to the SSRIs, described earlier, in that they effect neurotransmitters. However, the impact of amphetamins is broader in range. Dopamine, serotonin and noradrenalin (all neurotransmitters) are released from nerve cells and register effects in the reuptake process. Also similar to the SSRIs, the reuptake process for the serotonin is limited, or inhibited.

Side Effects of Amphetamines

Patients typically register some side effects which may include insomnia, dizziness and elevated blood pressure. Other people experience weight loss, diarrhea or euphoria. There are still other symptoms, so if you experience anything of the ordinary be certain to talk to your doctor. Symptoms differ greatly from person to person.

Product names in the ADHD realm are Adderall and Dexedrine, though much of the familiarity with amphetamines is tied to their reputation as a drug utilized by club goers. Of course, this is not a usage linked to or authorized by the medical, psychological or pharmaceutical industries; indeed recreational use of such drugs is utterly refuted and is in no way supported. For sufferers of depression the use of recreational drugs or alcohol can make treatment significantly more difficult.

One of the primary challenges that accompany amphetamine use, is the habit forming nature of the drug. Both physical and psychological dependencies can develop from this medication, and withdrawal effects can occur if dosages are eliminated suddenly. Typically, you need to consult with your physician to develop a plan for gradually phasing out amphetamine use.

Serotonin Syndrome

If the body generates too much of the neurotransmitter the result is serotonin syndrome. This is usually identified by an exacerbation of the standard SSRI side effects which may include nausea, anxiety, sexual dysfunction, or diarrhea. Further symptoms may include, but aren't limited to headaches, agitation, and drowsiness. Serotonin syndrome brings the added possibilities of agitation, dizziness, and shivering. Ask your doctor for a comprehensive list and consult him and her on any changes you notice.

Serotonin syndrome is brought on by the use of serotonogenic drugs, which include several types of antidepressants, tricyclics and MAOIs. Other substances which can contribute to serotonin syndrome include cocaine, L-tryptophan, Lithium, ecstasy, LSD, and, finally, amphetamines. Here it is clear that an open discussion with your doctor is always a good idea. By communicating how your body responds to any and all treatments will allow him or her to best be able to help in proper diagnosis.

Keeping the Balance

The human balance typically comes with a sophisticated sense of balance, and this even applies to our chemical makeup. When something like a selective serotonin reuptake inhibitor is introduce, it must be done with great care and under the supervision of a professional. Patients need to be aware of how an SSRI reacts with the body and also how it could respond to other treatments or drugs also being processed. As someone with an interest in treating depression, understanding the treatment options is truly critical to your recovery.