SAM-e

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SAM-e is a stabilized synthetic form of S-adenosylmethionine, a naturally occurring chemical in animals; SAM-e is made from the amino acid methionine and from ATP and is responsible for making many important compounds in the body. For those who suffer from depression, SAM-e has shown to have some beneficial effects, such as elevating mood. SAM-e has been available by prescription in Europe for a number of years and has been around as an over-the-counter supplement in the U.S. since around 1996. Along with other SSRI Drug Treatments, people take SAM-e for a variety of conditions including depression, chronic fatigue syndrome, and fibromyalgia, and osteoarthritis.

Key Role in Neurotransmitter Production

Recent studies have shown that SAM-e is essential in producing many neurotransmitters, some thought to adjust and elevate moods. For instance, it is thought that the supplement may increase the availability of serotonin and dopamine, thereby lessening the severity of depression. SAM-e has also been thought to improve mood in those suffering from Parkinson's disease, although there still exists a dispute about the safety of the supplement in these patients. It is also thought to have anti-inflammatory properties that can relieve arthritis symptoms and joint pain. Additionally, SAM-e may help to reduce liver toxicity in cancer patients who are undergoing chemotherapy.

Proper Precautions Necessary

As with any drug or supplement, there is some cautionary advice that one should be aware of before taking SAM-e. First of all, it is crucial to discuss using SAM-e with your doctor, as it may have unintended side effects with other drugs you are taking. Since it is available over-the-counter in the U.S., your dosage is less regulated and less supervised, which can prove dangerous. The cost of SAM-e is a drawback for many people, as the recommended dosage for those who suffer from depression is from 100 to 400 milligrams per day, and 200-milligram pills generally cost $.60-$.80 each; these expenses can certainly add up over time.

SAMe Side Effects

Nausea is the most common reported side effect; some other less frequently occurring side effects include skin rash, lowered blood sugar, dry mouth, thirst, increased urination, hyperactivity, headaches, nervousness, and insomnia. Another concern for SAM-e is that in certain instances it has been related to hypermania and mania, which could be harmful for those who suffer from bipolar disorder or anxiety disorders. As mentioned above, there are some physicians who say that tSAM-e may have adverse effects on those who suffer from Parkinson's disease. As with all medications, people interested should discuss it with their physician before beginning a regime. The long term side effects of taking SAM-e are not currently known, nor are many of its benefits.

Essentially, many more thorough studies need to be conducted about the effectiveness and possible dangers of taking SAM-e, though it is currently shown to be most beneficial for those with depression. Regardless of how effective SAM-e may be for you, it is important to speak with a physician regarding any SSRI supplement or drug you are interested in taking.